In vivo recovery of muscle contraction after alpha-bungarotoxin binding.
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چکیده
منابع مشابه
In vivo recovery of muscle contraction after alpha-bungarotoxin binding
Acetylcholine receptors were inactivated in vivo at the mouse neuromuscular junction using alpha-bungarotoxin (alpha-BTX). It was found that neurally produced muscle contraction recovered within 4-8 days (halftime similar to 3 days). Actinomycin D interfered with this recovery, but did not affect normal nerve-stimulated muscle contraction. If the response was initially eliminated by [125-I]alph...
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The carotid body is an arterial chemosensory organ which detects changes in blood gas tensions and pH, and reflexly contributes to the cardiorespiratory adjustments which occur during hypoxia, hypercapnia and acidosis. However, the sensory mechanisms involved in carotid chemoreception remain to be elucidated. Morphologically, the carotid body consists of an association of elemental units, or gl...
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Binding properties of detergent-solubilized receptors for alpha-bungarotoxin from skeletal muscle of the 13th day chick embryo and from optic lobe of the hatching chick were compared. It was found that both types of receptor are nicotinic, although they differ in their affinities for individual ligands and in the rank order of ligands. In contrast to the muscle receptor, the neuronal receptor b...
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The existence of nicotinic acetylcholine receptors (AChRs) on the motor nerve terminals of vertebrates has long been controversial. We have re-examined this issue by electron microscope autoradiography with [125I] alpha-bungarotoxin, following separation of nerve terminals from muscle fibers by collagenase and protease treatment. We found no label over nerve terminal membranes other than that d...
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Introduction The presence of nicotinic cholinergic receptors in mammalian brain has been suggested by a number of investigators with the application of nicotinic ligands [1, 2]. α-Bgtx is a selective antagonist of postsynaptic nicotinic acetylcholine receptors in vertebrate and insects. By the use of potent nicotinic antagonist Iα-Bgtx as a ligand, cholinergic nicotinic receptors has been ident...
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ژورنال
عنوان ژورنال: Journal of Cell Biology
سال: 1975
ISSN: 0021-9525,1540-8140
DOI: 10.1083/jcb.66.1.209